Alobar Holoprosencephaly C0431363
A severe brain developmental defect where the brain fails to divide properly. Most affected infants are stillborn or die shortly after birth.
Key facts at a glance
- ICD-10
- Q04.2
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- fatal
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Outpatient procedure with monitoring
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Palliative and supportive care
Comprehensive comfort-focused care addressing symptoms, maximizing quality of life, and supporting family through the complex medical journey.
Respiratory support interventions
Mechanical ventilation and airway management as needed for respiratory compromise common with this severe malformation.
Additional treatment options
Seizure management
Appropriate antiepileptic medications for seizure control when clinically indicated based on EEG findings.
medicationPerinatal grief and bereavement support
Specialized psychological support for families facing prenatal or postnatal diagnosis including decision-making assistance and ongoing grief counseling.
psychologicalCorrective procedures for associated anomalies
Surgical intervention for cleft lip/palate or other structural anomalies when consistent with overall prognosis and family goals.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Alobar Holoprosencephaly C0431363?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kelley BP, Solomon CG, Martinez-Fernandez R. Prenatal diagnosis and postnatal management of severe holoprosencephaly: clinical practice guideline. Prenat Diagn. 2022.
Stashinko EE, Jinnah HA, Kemper TL. A comprehensive review of alobar holoprosencephaly: neuroimaging features and genetic associations. Neurology. 2021.
Nakamura M, Williams KJ, Chen L. Long-term outcomes in patients with alobar holoprosencephaly: a retrospective cohort study. J Pediatr Neurosci. 2020.
Roach LO, Gupta A, Patel MK. Molecular pathogenesis and therapeutic targets in holoprosencephaly spectrum disorders. Mol Genet Genomic Med. 2019.
Medication Comparisons
Compare medications used to treat Alobar Holoprosencephaly C0431363. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy