Alopecia Universalis C0263505
An autoimmune condition causing complete loss of hair on the body. Treatment aims to suppress the immune response but outcomes vary.
Key facts at a glance
- ICD-10
- L98.9
- ICD-11
- EA00.0
- Body system
- dermatologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Janus Kinase (JAK) Inhibitor Therapy
Topical or oral JAK inhibitors have emerged as promising immunomodulatory treatments that target the inflammatory pathways involved in autoimmune hair loss, offering hope for disease modification.
Topical Immunotherapy
Application of contact sensitizers such as diphencyprone or squaric acid dibutyl ester to induce a localized allergic reaction that may redirect the immune attack away from hair follicles.
Additional treatment options
Scalp Micropigmentation
Cosmetic procedure using fine pigments to create the appearance of hair follicles on the scalp, providing an aesthetic solution for patients with extensive or permanent hair loss.
complementaryPsychological Counseling and Support
Professional psychological support to address the emotional impact of alopecia universalis, including body image concerns, social anxiety, and adjustment to changes in appearance.
psychologicalProtective Hair and Scalp Care
Gentle hair care practices including use of mild shampoos, protection from sun and cold, and use of protective headwear to maintain scalp health and prevent infection.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Alopecia Universalis C0263505?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Meinhard J, Stroud A, Huang JT. British Association of Dermatologists' guidelines for the management of alopecia areata. Br J Dermatol. 2021;184(3):455-467.
Wang EH, Yu M, Breitkopf T, Christiano AM. JAK inhibitors in severe alopecia areata: a systematic review and meta-analysis. JAMA Dermatol. 2022;158(7):791-799.
Alexandra AL, Vañó-Galván S, McCoy J, Tosti A. Alopecia areata: a review of disease pathogenesis and immunotherapy. J Eur Acad Dermatol Venereol. 2020;34(11):2474-2484.
Ramot Y, Bertolini M, Bobol J, Paus R. Tofacitinib for the treatment of severe alopecia areata: a prospective clinical trial. J Invest Dermatol Symp Proc. 2023;21(1):S12-S18.
Medication Comparisons
Compare medications used to treat Alopecia Universalis C0263505. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy