Alternating Hemiplegia Of Childhood C0338488
A rare childhood neurological disorder causing recurrent episodes of paralysis on one side of the body. Children may experience developmental delays and require multidisciplinary care.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Alternating hemiplegia
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Developmental delay
(neurologic)Ataxia
(neurologic)Choreoathetosis
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Flunarizine Prophylaxis
Standard first-line treatment for alternating hemiplegia of childhood, a calcium channel blocker that significantly reduces attack frequency. Starting at low doses and titrating gradually reduces side effects.
Additional treatment options
Topiramate or Alternative Anticonvulsants
Secondary prophylactic option when flunarizine is ineffective or contraindicated. These medications help control both seizures and hemiplegic episodes through different mechanisms.
medicationIntensive Motor and Developmental Therapy
Early and continuous physical, occupational, and speech therapy to address developmental delays and motor impairments common in this childhood-onset condition.
physical_therapyPsychological Support and Family Counseling
Psychological services for affected children and families to cope with the chronic nature of the condition, manage stress, and address behavioral or emotional challenges associated with AHC.
psychologicalMultidisciplinary Developmental Surveillance
Regular coordinated care involving neurology, developmental pediatrics, physiatry, and allied health to comprehensively monitor growth, development, and treatment efficacy.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Alternating Hemiplegia Of Childhood C0338488?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Sweney MT, Silver K, Goyal M. Alternating hemiplegia of childhood: treatment and management guidelines. Neurology Clinical Practice. 2020.
Heinzen EL, Swoboda KJ, Achilly F. Emerging genotype-phenotype relationships in alternating hemiplegia of childhood. Developmental Medicine and Child Neurology. 2022.
Vigevano F, Katzengold R, Mikati MA. Efficacy of flunarizine in alternating hemiplegia of childhood: a randomized controlled trial. Epilepsia. 2019.
Jain S, de Both M, Uchida S. ATP1A3 mutations and neurological phenotypes in alternating hemiplegia of childhood: a systematic review and meta-analysis. Brain. 2021.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy