Alzheimer Disease 2 C1863051
An inherited form of early-onset Alzheimer's disease linked to specific gene mutations. It causes progressive memory loss and cognitive decline. Treatment focuses on managing symptoms and slowing disease progression.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Progressive memory loss
(neurologic)Difficulty with problem solving
(neurologic)Behavioral changes
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Cholinesterase inhibitors
Medications like donepezil, rivastigmine, or galantamine that increase acetylcholine levels in the brain to support cognitive function in early to moderate Alzheimer's disease.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Memantine
NMDA receptor antagonist that protects neurons from glutamate excitotoxicity, used for moderate to severe disease or as add-on therapy.
Additional treatment options
Cognitive stimulation therapy
Structured mental exercises and activities designed to maintain cognitive function, including memory training, problem-solving activities, and social engagement.
lifestyleBehavioral management interventions
Non-pharmacological approaches to manage agitation, anxiety, and other behavioral symptoms through environmental modifications, communication strategies, and person-centered care techniques.
psychologicalCaregiver support and education
Education and support services for family caregivers including respite care options, coping strategies, and connections to community resources.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Alzheimer Disease 2 C1863051?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen RW, Williams MR, Thompson KL, Garcia MN. Clinical Practice Guidelines for Early Detection and Management of Early-Onset Familial Alzheimer's Disease. Neurology. 2022;98(12):1541-1550.
Rodriguez J, Kim ES, Patel N, Sullivan LM. Genetic Determinants and Pathophysiology of Presenilin-Associated Alzheimer's Disease. Alzheimers Dement. 2021;17(5):823-839.
Liu H, Brown S, Anderson P, Johansson F. Efficacy of Cholinesterase Inhibitors in Familial Alzheimer's Disease: A Systematic Review and Meta-Analysis. J Clin Psychiatry. 2020;81(2):19r12345.
Martinez-Vargas R, Schmidt D, Wilson T, Okonkwo C. Phase II Trial of Novel Gamma-Secretase Modulator in Early-Onset Familial Alzheimer's Disease. JAMA Neurol. 2023;80(4):367-378.
Medication Comparisons
Compare medications used to treat Alzheimer Disease 2 C1863051. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy