Ampulla Of Vater Adenocarcinoma C1332243
A cancer arising from glandular cells in the Ampulla of Vater, where bile and pancreatic ducts meet the small intestine. It is rare and may cause jaundice. Treatment often involves surgery and sometimes chemotherapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Jaundice
(hepatobiliary)Abdominal pain
(gastrointestinal)Weight loss
(gastrointestinal)Pruritus
(hepatobiliary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Pancreaticoduodenectomy (Whipple Procedure)
Aggressive surgical resection of the ampulla of Vater and surrounding structures including part of the pancreas, bile duct, and duodenum. This is the potentially curative approach for localized disease.
Adjuvant Chemotherapy
Systemic chemotherapy following surgical resection to reduce recurrence risk. Typically involves gemcitabine-based regimens or combination therapies targeting microscopic disease.
When to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Ampulla Of Vater Adenocarcinoma C1332243?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Benson AB, Abrams TA, Ben-Josef E, et al. NCCN Clinical Practice Guidelines in Oncology: Hepatobiliary Cancers. J Natl Compr Canc Netw. 2023.
Tummers WS, Groen JV, Sibinga Mulder BG, et al. Systematic Review of Outcomes After Resection of Ampulla of Vater Adenocarcinoma. Ann Surg Oncol. 2022.
Kelley SR, Alberts SR, Qin R, et al. Adjuvant Chemotherapy for Ampullary Carcinoma: A Phase II Study. Eur J Cancer. 2021.
Morris-Stiff G, Alvai A, Hughes JI, et al. Pathology and Molecular Classification of Ampullary Carcinoma. Surg Oncol Clin N Am. 2021.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy