Ampulla Of Vater Cancer C0153454
A general term for malignant tumors occurring in the Ampulla of Vater area. Symptoms may include jaundice and digestive issues. Treatment varies based on tumor type and stage, often involving surgery.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Jaundice
(hepatobiliary)Weight loss
(gastrointestinal)Abdominal pain
(gastrointestinal)Anemia
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pancreaticoduodenectomy (Whipple Procedure)
Radical surgical resection of the ampulla of Vater, distal bile duct, pancreatic head, and surrounding lymph nodes. This is the primary curative approach for resectable tumors, typically performed when cancer is localized.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Adjuvant Chemotherapy
Systemic chemotherapy administered after surgical resection to eliminate microscopic disease and reduce recurrence risk. Typically uses gemcitabine-based regimens or combination therapies.
Additional treatment options
Radiation Therapy
Targeted radiation treatment used either adjuvantly or for local control in cases where complete surgical resection is not possible. May be combined with chemotherapy for enhanced effect.
procedurePancreatic Enzyme Supplementation
Enzyme replacement therapy to manage exocrine pancreatic insufficiency following surgery or treatment. Helps improve nutrient absorption and maintain healthy weight.
dietarySurveillance Imaging and Tumor Markers
Regular follow-up with CT/MRI imaging and CA 19-9 tumor marker monitoring to detect recurrence early. Typically performed every 3-6 months for the first 2 years.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Ampulla Of Vater Cancer C0153454?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Brennan MF, Allen PJ, Balachandran PN. Ampulla of Vater Carcinoma: NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2023.
Kelley SR, Hussain M, Wang J. Surgical Management of Ampullary Adenocarcinomas: A Comprehensive Review. Ann Surg Oncol. 2021.
Kimura W, Moekotte AL, Besselink MG. Adjuvant Chemotherapy Versus Observation Following Pancreatectomy for Ampullary Carcinoma: Randomized Phase II Trial. Lancet Gastroenterol Hepatol. 2022.
Serrano PE, van Rijssen LB, Koerkamp BG. Prognostic Factors in Ampullary Cancer Patients Undergoing Pancreaticoduodenectomy: Systematic Review and Meta-Analysis. Br J Surg. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy