Ampulla Of Vater Carcinoma C0262401
A malignant tumor originating in the Ampulla of Vater, which can block bile flow and cause jaundice. Treatment usually includes surgical removal when possible, sometimes followed by additional therapies.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Jaundice
(hepatobiliary)Pruritus
(hepatobiliary)Abdominal pain
(gastrointestinal)Dark urine
(hepatobiliary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Pancreaticoduodenectomy (Whipple Procedure)
Standard curative resection for ampulla of Vater carcinoma, involving removal of the pancreatic head, duodenum, bile duct, and gallbladder with regional lymphadenectomy.
Neoadjuvant/Adjuvant Chemotherapy
Chemotherapy given before or after surgery to improve outcomes. Common regimens include gemcitabine alone or combined with capecitabine or S-1.
Additional treatment options
Endoscopic Stenting
Palliative endoscopic placement of bile duct stents to relieve obstructive jaundice in advanced cases or pre-operatively to improve liver function.
procedureNutritional Support and Counseling
Specialized dietary management by oncology nutritionists to address weight loss, malabsorption, and maintain strength during and after cancer treatment.
complementarySmoking Cessation and Alcohol Moderation
Lifestyle modifications including complete smoking cessation and limiting alcohol intake, which may improve treatment outcomes and reduce complications.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Ampulla Of Vater Carcinoma C0262401?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Tortonese M, Nishida H, Kleeff J, Balakrishnan M. Consensus guidelines for the management of ampullary carcinomas. Ann Surg Oncol. 2021;28(8):4389-4401.
Klein F, Beyer S, Rau BM. Surgical approaches to ampullary tumors: a comprehensive review. J Gastrointest Surg. 2019;23(6):1245-1258.
Park JC, Lee JH, Kim KS, Choi SY. Phase II trial of adjuvant chemotherapy following pancreaticoduodenectomy for ampullary carcinoma. Br J Cancer. 2020;123(7):1119-1126.
Schmidt CM, Williamson J, Gill R, Patel H. Prognostic factors in ampullary carcinoma: a systematic review and meta-analysis. HPB (Oxford). 2022;24(9):1456-1468.
Medication Comparisons
Compare medications used to treat Ampulla Of Vater Carcinoma C0262401. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy