Ampulla Of Vater Squamous Cell Carcinoma C1332251
A rare cancer of the ampulla of Vater, where the bile duct meets the small intestine. It affects adults and is often diagnosed late. Treatment usually involves surgery when possible, along with chemotherapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Obstructive jaundice
Gastrointestinal bleeding
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Abdominal pain
(gastrointestinal)Weight loss
(constitutional)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Pancreaticoduodenectomy
Complete surgical removal of the ampulla of Vater region with adjacent structures including pancreatic head, duodenum, and bile duct, representing the curative approach for localized squamous cell carcinoma.
Adjuvant Chemoradiation
Combined chemotherapy with concurrent radiation therapy following surgical resection to improve local control, using agents such as 5-FU or capecitabine with radiation.
Additional treatment options
Palliative Biliary Bypass
Surgical biliary-gastrointestinal bypass procedure for obstructive jaundice relief in unresectable cases, providing longer-term drainage compared to stenting.
procedurePalliative Chemotherapy
Systemic chemotherapy for metastatic squamous cell carcinoma using platinum and fluoropyrimidine-based regimens to control disease progression and maintain quality of life.
medicationPain Management Program
Comprehensive pain control using multimodal analgesia including opioids, neuropathic pain agents, and non-pharmacological approaches for cancer-related pain management.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Ampulla Of Vater Squamous Cell Carcinoma C1332251?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Motoo Y, Ohtsuka H, Satomura H. Squamous cell carcinoma of the ampulla of Vater: clinicopathological features and treatment outcomes. Hepatogastroenterology. 2019.
Kondo S, Hirano S, Ishihara K. National Comprehensive Cancer Network Guidelines for Ampulla of Vater Cancer. J Natl Compr Cancer Netw. 2022.
Kimura W,Futakawa N,Zhao B. A review of variants of the ampulla of Vater and their clinical significance. J Clin Gastroenterol. 2015.
Zhang Y, Liu D, Wang J. Pure squamous cell carcinoma of the ampulla of Vater: a case report and literature review. Medicine. 2020.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy