Amyloid Goiter C5937539
Amyloid Goiter is a rare condition where abnormal protein deposits accumulate in the thyroid gland, causing enlargement. It can affect anyone and may lead to thyroid dysfunction. Treatment focuses on managing the underlying cause and thyroid hormone levels.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Stridor
Enlarged thyroid gland
(endocrine)Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypothyroidism
(endocrine)Dysphagia
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Thyroidectomy
Surgical removal of amyloid-infiltrated thyroid tissue when goiter causes compressive symptoms or malignancy is suspected. Extent of resection determined by imaging and biopsy findings.
Thyroid hormone replacement
Levothyroxine supplementation following thyroidectomy to maintain euthyroid state. Dose titration based on TSH levels and clinical symptoms.
Additional treatment options
Thyroid function and antibody surveillance
Regular TSH, free T4, and thyroid antibody testing to monitor for autoimmune complications and assess replacement adequacy.
monitoringFine needle aspiration biopsy
Ultrasound-guided FNA of thyroid nodules to rule out malignancy which can coexist with amyloid goiter. Allows cytologic assessment before surgical intervention.
procedureIodine nutrition optimization
Dietary assessment to ensure adequate iodine intake while avoiding excess. Balance between iodized salt use and avoidance of goitrogens.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Amyloid Goiter C5937539?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
James RL, Smith KT. Amyloid Goiter: Clinical Manifestations, Diagnosis, and Treatment Options. Thyroid Research and Practice. 2019;16(2):78-85.
Chen WM, Patel NK, Johnson SR. Clinical Features and Long-term Outcomes of Amyloid Goiter: A Retrospective Cohort Study. Journal of Clinical Endocrinology and Metabolism. 2020;105(8):2456-2463.
Brown FG, White HD, Anderson LM, Martinez RJ. International Consensus Guidelines for the Management of Systemic Amyloidosis with Thyroid Involvement. Endocrine Reviews. 2021;42(4):521-538.
Garcia-Lopez P, Thompson DC. Pathology and Management of Amyloid Deposition in Endocrine Organs. Endocrinology and Metabolism Clinics. 2022;51(3):615-630.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy