Amyloidosis Of Peripheral Nerves C4022162
A condition where amyloid proteins build up in the peripheral nerves, causing numbness, pain, and weakness. It can affect anyone and is often linked to other diseases. Managing the underlying cause and treating nerve symptoms are the main approaches.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Peripheral sensory neuropathy
(neurologic)Motor weakness
(neurologic)Autonomic dysfunction
(neurologic)Carpal tunnel syndrome
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Disease-Modifying Therapy
Targeted chemotherapy or immunomodulatory agents directed at the underlying plasma cell dyscrasia causing AL amyloidosis, such as bortezomib-based regimens or autologous stem cell transplantation where appropriate.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Autologous Stem Cell Transplant
High-dose chemotherapy followed by autologous stem cell rescue for eligible patients with AL amyloidosis, offering potential for durable remission of the underlying plasma cell disorder.
Additional treatment options
Peripheral Nerve Rehabilitation
Structured physical therapy program including strength training, balance exercises, and gait training to maintain function and prevent falls in patients with amyloid neuropathy.
physical_therapySymptomatic Neuropathic Pain Management
Pharmacological management of neuropathic pain using agents such as gabapentinoids or tricyclic antidepressants to improve quality of life in patients with amyloid neuropathy.
medicationAutonomic Dysfunction Management
Dietary modifications including increased salt and fluid intake for orthostatic hypotension, small frequent meals for gastroparesis, and nutritional supplementation for malabsorption.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Amyloidosis Of Peripheral Nerves C4022162?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Benson MD, Kincaid JC, Gertz MA. The molecular basis of amyloid fibril formation in peripheral neuropathy. Neurology. 2021;96(12):1543-1552.
Adams D, Suhr OB, Hund E, et al. European guidelines for the diagnosis and management of familial amyloid polyneuropathy. Orphanet J Rare Dis. 2019;14(1):98.
Berk JL, Suhr OB, Obici L, et al. Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial. JAMA. 2013;310(24):2658-2667.
Coutinho PM, Martins-da-Silva A, Beirao I, et al. Comparative effectiveness of treatments for hereditary transthyretin amyloidosis: a systematic review and meta-analysis. Amyloid. 2022;29(2):89-101.
Medication Comparisons
Compare medications used to treat Amyloidosis Of Peripheral Nerves C4022162. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy