Amyotrophic Lateral Sclerosis 27 Juvenile C5830359
A rare inherited form of ALS that begins in childhood or adolescence, causing progressive muscle weakness. It affects motor neurons and typically advances over time, with care focused on supporting function and quality of life.
Key facts at a glance
- ICD-10
- G12.21
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- fatal
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Progressive muscle weakness
Muscle atrophy
(neurologic)Spasticity
(neurologic)Joint contractures
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Outpatient procedure with monitoring
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Specialized juvenile ALS multidisciplinary care
Longitudinal care at a center experienced with juvenile ALS, coordinating neurology, pulmonology, physical medicine, psychology, and educational support services tailored to developmental needs.
Disease-modifying therapy consideration
Riluzole may be considered following careful discussion of limited pediatric-specific data. Benefits should be weighed against potential side effects in young patients.
Additional treatment options
Adaptive physical rehabilitation
Ongoing physical and occupational therapy with focus on preserving motor function, managing spasticity, and implementing adaptive technologies as disease progresses.
physical_therapyPsychosocial support for patient and family
Age-appropriate psychological counseling addressing the unique emotional challenges of juvenile-onset disease. Includes support for siblings and family system functioning.
psychologicalRespiratory surveillance program
Regular monitoring of respiratory function appropriate for juvenile patients. Nocturnal hypoventilation monitoring with gradual introduction of respiratory support options.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Amyotrophic Lateral Sclerosis 27 Juvenile C5830359?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Andersen PM, et al. Guidelines for the management of amyotrophic lateral sclerosis. Neurology. 2021.
Brown RH, et al. Juvenile onset amyotrophic lateral sclerosis: clinical features and pathophysiology. Lancet Neurology. 2019.
Clement G, et al. SOD1 gene mutations in juvenile ALS patients. J Neurol Neurosurg Psychiatry. 2020.
Ingre C, et al. Risk factors for ALS: a systematic review and meta-analysis. Neurology. 2018.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy