Amyotrophic Lateral Sclerosis Type 3 C1847735
An inherited form of ALS that typically begins in mid-adulthood and causes progressive motor neuron damage. It leads to worsening muscle weakness and may require breathing support as the disease progresses.
Key facts at a glance
- ICD-10
- G12.21
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- fatal
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Progressive muscle weakness
(neurologic)Fasciculations (muscle twitching)
(neurologic)Spasticity (muscle stiffness)
(neurologic)Respiratory insufficiency
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antioxidant and neuroprotective therapy
Edaravone, an intravenous free radical scavenger, is FDA-approved for ALS to reduce oxidative stress. Treatment involves cycles of daily infusions followed by rest periods under specialist supervision.
Minimally invasive procedural intervention
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Non-invasive ventilation initiation
Bilevel positive airway pressure support when respiratory muscle weakness develops. Nocturnal use helps maintain adequate oxygenation and reduces respiratory fatigue during disease progression.
Additional treatment options
Acupuncture and integrative therapies
Supportive acupuncture may help manage pain, fatigue, and stress. Complementary approaches including massage and relaxation techniques complement conventional care.
complementaryFeeding tube placement
Percutaneous endoscopic gastrostomy provides reliable nutrition when dysphagia compromises oral intake. Elective placement before respiratory compromise reduces procedural risk.
surgicalAssistive device optimization
Progressive provision of mobility aids, communication devices, and home modifications. Occupational therapy assessment identifies needs and trains patients in equipment use.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Amyotrophic Lateral Sclerosis Type 3 C1847735?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Andersen PM, Abrahams S, Borasio GD, et al. EFNS guidelines on the clinical management of amyotrophic lateral sclerosis. Eur J Neurol. 2012.
Kiernan MC, Vucic S, Cheah BC, et al. Amyotrophic lateral sclerosis. Lancet. 2011.
Benatar M, Wuu J, McHale J, et al. Randomized, double-blind, placebo-controlled trial of arimoclomol in SOD1 ALS. Neurology. 2022.
Pupillo E, Messina P, Logroscino G, et al. Long-term survival in amyotrophic lateral sclerosis: a population-based study. J Neurol Neurosurg Psychiatry. 2014.
Medication Comparisons
Compare medications used to treat Amyotrophic Lateral Sclerosis Type 3 C1847735. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy