Anaplastic Pleomorphic Xanthoastrocytoma C4283858
A rare, aggressive brain tumor typically affecting children and young adults. Treatment involves surgery, radiation, and chemotherapy. Outlook varies based on individual factors.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Headache
Focal neurological deficit
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Visual disturbances
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Gross Total Resection
Complete surgical removal of the tumor whenever feasible, as extent of resection significantly impacts progression-free and overall survival in anaplastic pleomorphic xanthoastrocytoma.
BRAF-Targeted Therapy
Use of BRAF inhibitors such as dabrafenib, particularly for tumors harboring BRAF V600E mutations. These targeted agents block specific molecular pathways driving tumor growth.
Additional treatment options
Focal Radiation Therapy
Precision radiation targeting the tumor bed and any residual disease. Particularly valuable when complete resection is not achievable or for recurrent disease.
procedureMEK Inhibitor Therapy
Targeted therapy using MEK inhibitors like trametinib, often used in combination with BRAF inhibitors to overcome resistance mechanisms in tumors with MAPK pathway alterations.
medicationMultimodal Surveillance
Integrated monitoring including regular MRI scans, neurological examinations, and assessment of treatment-related complications. Imaging protocols may include advanced sequences to distinguish treatment effects from progression.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anaplastic Pleomorphic Xanthoastrocytoma C4283858?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Weller M, van den Bent M, Preusser M, et al. EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. Nat Rev Clin Oncol. 2021.
Kaufman LJ, Horbinski CM. Pleomorphic xanthoastrocytoma and anaplastic pleomorphic xanthoastrocytoma: pathology, clinical features, and prognosis. J Neurooncol. 2022.
Chiang J, Khuwa S, Rodriguez FJ, et al. Treatment outcomes in anaplastic pleomorphic xanthoastrocytoma: a retrospective multi-institutional analysis. Neuro Oncol. 2020.
Di Pisa A, Capra L, Mazzei L, et al. Molecular characterization of anaplastic pleomorphic xanthoastrocytoma: BRAF V600E mutation and CDKN2A status. Acta Neuropathol. 2019.
Medication Comparisons
Compare medications used to treat Anaplastic Pleomorphic Xanthoastrocytoma C4283858. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy