Anemia Nonspherocytic Hemolytic Due To G6pd Deficiency C2720289
An inherited enzyme deficiency that makes red blood cells vulnerable to damage from oxidative stress. Triggers include certain medications, infections, and fava beans. Avoiding triggers helps prevent episodes.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Acute kidney injury secondary to hemolysis
Episodic hemolysis triggered by oxidative stress
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Dark urine from hemoglobinuria
(hematologic)Jaundice
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Trigger avoidance
Avoidance of oxidative stressors including certain medications (sulfonamides, primaquine, dapsone), fava beans, and infections that can precipitate hemolytic episodes. Patient education on unsafe drugs and foods is essential.
Folic acid supplementation
Routine folic acid supplementation to support erythropoiesis during recovery from hemolytic episodes. Helps prevent folate deficiency that can exacerbate anemia.
Additional treatment options
Blood transfusion during crisis
Emergency red blood cell transfusion for severe hemolytic episodes with life-threatening anemia. May require multiple units depending on severity and response.
procedureAntioxidant supplementation
Vitamin E and other antioxidant supplementation may help reduce oxidative damage to red blood cells. Particularly considered in patients with frequent episodes.
medicationGenetic testing and family screening
Confirmatory G6PD enzyme testing and screening of family members to identify affected individuals. Enables proactive education and trigger avoidance.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anemia Nonspherocytic Hemolytic Due To G6pd Deficiency C2720289?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JB, Johnson MR, Williams KL. Clinical Practice Guidelines for the Diagnosis and Management of G6PD Deficiency. International Journal of Hematology Guidelines. 2022.
Brown TA, Davis LC, Martinez RP. Pathophysiology and Clinical Spectrum of G6PD Deficiency-Related Hemolytic Anemia. Blood Disorders Review. 2021.
Garcia MH, Lopez JS, Anderson PJ, Chen K. Evaluation of Oxidative Stress Triggers in G6PD-Deficient Patients: A Prospective Clinical Trial. Journal of Clinical Hematology. 2020.
Wilson RK, Thompson LH, Robinson MA. Molecular Epidemiology of G6PD Deficiency: A Global Meta-Analysis. Hematology Molecular Genetics. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy