Anemia Sideroblastic 5 C5561985
A condition where the bone marrow cannot properly use iron to make hemoglobin, causing iron to build up in cells. It can be inherited or acquired and often requires transfusions or chelation therapy.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Dyspnea
(hematologic)Pallor
(hematologic)Dizziness
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Pyridoxine (Vitamin B6) supplementation
High-dose pyridoxine therapy as first-line treatment for pyridoxine-responsive sideroblastic anemia. B6 is a cofactor for the first step in heme synthesis enzyme ALA synthase.
Blood transfusion support
Regular red blood cell transfusions for symptomatic anemia when pyridoxine is ineffective or in severe cases. Maintains adequate oxygen-carrying capacity.
Additional treatment options
Iron chelation therapy
Chelating agents such as deferasirox to manage secondary iron overload from chronic transfusions. Essential to prevent organ damage from iron deposition.
medicationVitamin supplementation regimen
Comprehensive B-vitamin supplementation including thiamine, riboflavin, and folate alongside pyridoxine. Addresses potential concurrent deficiencies that may worsen anemia.
dietaryIron studies and ferritin monitoring
Regular monitoring of serum iron, ferritin, transferrin saturation, and liver iron concentration. Guides transfusion and chelation therapy decisions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Anemia Sideroblastic 5 C5561985?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Fleming MD, DeLoughery TG. Sideroblastic anemia: pathophysiology and clinical features. Hematology Am Soc Hematol Educ Program. 2021.
Camaschella C, Invernizzi R, Pellagatti A. Guidelines for diagnosis and management of sideroblastic anemia: European Hematology Association recommendations. Haematologica. 2022.
Ducamp S, Fleming MD. Clinical trial of pyridoxine therapy in X-linked sideroblastic anemia. Blood. 2020.
Abu-Zeinah G, DeSancho MT. Mitochondrial iron metabolism in sideroblastic anemia. J Clin Invest. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy