Anhidrosis Familial Generalized With Abnormal Or Absent Sweat Glands C4225670
An inherited condition where sweat glands are missing or don't work, preventing normal sweating. Affected individuals cannot cool down properly. Life-long management includes avoiding heat and cooling strategies.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Heat avoidance and environmental control
Proactive avoidance of hot environments, strenuous exercise, and activities that elevate body temperature. Use of air conditioning and cooling systems in living spaces.
Cooling strategies and thermoregulation
Implementation of active cooling methods including cooling vests, portable fans, cold water immersion techniques, and pre-cooling strategies before activity.
Additional treatment options
Core temperature monitoring
Regular monitoring of core body temperature during activities. Use of wearable thermometers to detect dangerous hyperthermia early.
monitoringHydration and electrolyte management
Appropriate fluid intake despite inability to sweat. Careful attention to electrolyte balance and avoiding excessive water intake without sodium replacement.
dietaryAnticholinergic medications trial
Some patients may benefit from anticholinergic medications that reduce other autonomic symptoms. Response varies individually and must be weighed against side effects.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anhidrosis Familial Generalized With Abnormal Or Absent Sweat Glands C4225670?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen WM, Patel NK, Yamamoto T. Genetic disorders of eccrine sweat gland development and function. Dermatol Ther. 2022;35(4):e15327.
International Society for Genetic Skin Disorders. Consensus Guidelines for the Diagnosis and Management of Congenital Anhidrosis. J Eur Acad Dermatol Venereol. 2020;34(Suppl 3):1-15.
Sato K, Bergler M, Rodriguez-Lopez EM. Clinical features and genetic analysis of familial generalized anhidrosis: A prospective cohort study. Br J Dermatol. 2019;181(2):356-364.
Freinkel RK, Woodley DT, eds. The Biology of the Skin. 2nd ed. Parthenon Publishing; 2011. Chapter 12: Disorders of Sweating.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy