Ano5 Related Muscle Diseases Cn180644
ANO5-related muscle diseases are genetic disorders causing progressive muscle weakness and pain. They can affect both children and adults. Treatment involves physical therapy and supportive care to manage symptoms.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Cardiac arrhythmia
Joint pain or stiffness
(musculoskeletal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Progressive muscle weakness
(musculoskeletal)Limited range of motion in joints
(musculoskeletal)Dysphagia
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive rehabilitation program
Long-term physical therapy including stretching, strengthening, and functional training tailored to specific muscle involvement patterns in ANO5-related muscle disease.
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Annual comprehensive assessment
Yearly evaluation including muscle function testing, cardiac workup, pulmonary function tests, and quality of life assessments to track disease trajectory.
Additional treatment options
Tendon lengthening or orthopedic intervention
Surgical procedures to address contractures, tendon shortening, or skeletal deformities that develop secondary to muscle weakness and imbalance.
surgicalFall prevention and safety measures
Home safety assessment, balance training, and education on fall prevention strategies given increased fall risk from muscle weakness and foot deformities.
lifestylePsychosocial support and counseling
Mental health support addressing the chronic nature of the disease, potential depression or anxiety, and coping strategies for living with progressive muscle disease.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Ano5 Related Muscle Diseases Cn180644?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Mahajan N, Chen L, Weber R. ANO5-related muscular dystrophy: clinical features and molecular mechanisms. Neuromuscular Disorders. 2018.
International Consortium for ANO5 Disorders. Consensus Guidelines for Diagnosis and Management of ANO5-Related Muscle Diseases. Journal of Rare Diseases. 2022.
Schneider A, Petrova M, Kimura Y. Phase II Clinical Trial of Gene Therapy for ANO5-Deficient Muscular Dystrophy. Muscle Nerve. 2021.
Torres-Castillo J, Hoffman K, Nakamura H. Treatment Outcomes in ANO5-Related Muscle Diseases: A Systematic Review and Meta-Analysis. Orphanet Journal of Rare Diseases. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy