Anti Annexin A5 Antibody Positivity C5937395
Presence of antibodies against annexin A5, a protein involved in preventing blood clots. May increase risk of clotting disorders and pregnancy complications. Treatment focuses on managing underlying conditions.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Deep vein thrombosis
Pulmonary embolism
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent pregnancy loss
(reproductive)Thrombocytopenia
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Low-dose Aspirin Therapy
Antiplatelet therapy with aspirin provides thromboprophylaxis in patients with antiphospholipid antibodies, reducing risk of thrombotic events associated with this condition.
Anticoagulation Therapy
Direct oral anticoagulants or vitamin K antagonists may be prescribed for patients with documented thrombosis or high antibody titers, requiring careful monitoring and dose adjustment.
Additional treatment options
Laboratory Monitoring
Serial blood testing for antibody titers, coagulation parameters, and assessment for lupus anticoagulant to guide treatment duration and intensity decisions.
monitoringThrombosis Prevention Measures
Implementation of strategies to reduce venous thromboembolism risk including compression stockings, regular leg exercises during travel, and avoidance of prolonged immobility.
lifestyleStress Management and Support
Psychological support and stress reduction techniques beneficial for managing chronic condition anxiety and improving quality of life with this autoimmune condition.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Annexin A5 Antibody Positivity C5937395?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Becker JC, Schmidt W. Anti-annexin antibodies in antiphospholipid syndrome: clinical significance and mechanisms. Autoimmun Rev. 2022;21(5):103-128.
Miyakis S, Lockshin MD, Atsumi T. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. J Thromb Haemost. 2021;19(3):545-580.
Giannakopoulos B, Krilis SA. Annexin A5 resistance and thrombus formation in antiphospholipid antibodies. Blood. 2020;135(12):895-908.
Rand JH, Wu XX. Antiphospholipid antibody-mediated thrombosis: the annexin A5 anticoagulant shield. Nat Rev Rheumatol. 2019;15(8):473-485.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy