Anti Annexin V Antibody Positivity C5676697
Presence of antibodies against annexin V, which normally helps prevent excessive blood clotting. May be associated with increased clotting risk and pregnancy complications. Management involves monitoring and treating underlying causes.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Venous thrombosis
Arterial thrombosis
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pregnancy complications
(reproductive)Livedo racemosa
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anticoagulation therapy
Low molecular weight heparin or warfarin therapy to reduce thrombotic risk associated with antiphospholipid antibodies. Regular INR monitoring is required for warfarin users to maintain therapeutic range.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Low-dose aspirin
Antiplatelet therapy to reduce clot formation risk by inhibiting platelet aggregation. Often used in combination with anticoagulants for high-risk patients.
Additional treatment options
Regular antiphospholipid antibody testing
Periodic monitoring of antibody titers to assess disease activity and treatment response. Testing typically includes lupus anticoagulant, anticardiolipin, and anti-beta-2-glycoprotein I antibodies.
monitoringCardiovascular risk reduction
Smoking cessation, maintaining healthy weight, and regular moderate exercise to reduce overall thrombotic risk. Physical activity improves endothelial function and circulation.
lifestylePregnancy surveillance program
Enhanced obstetric monitoring including frequent ultrasounds, Doppler studies, and coagulation testing for women with history of pregnancy complications. Aims to detect placental insufficiency early.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Annexin V Antibody Positivity C5676697?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome. J Thromb Haemost. 2012;10(2):251-258.
Gomez G, Rodriguez-Garcia J, Tincani A, Loizou S. Anti-annexin V antibodies: clinical significance and detection methods. Autoimmun Rev. 2019;18(5):432-440.
Sciascia S, Amigo MC, Roca A, Cuadrado MJ. Treatment of thrombotic APS with direct oral anticoagulants: a systematic review and meta-analysis. Rheumatology. 2021;60(3):1129-1138.
Abrahams VM, Chamley LW, Salmon J. Antiphospholipid syndrome and pregnancy: understanding the mechanisms. Obstet Gynecol Surv. 2020;75(4):203-215.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy