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Anti Centromere Protein B Antibody Positivity C5676675

Published: July 22, 2026Updated: August 20, 2026

Antibodies targeting centromere protein B, frequently seen in limited systemic sclerosis. May indicate risk for CREST syndrome features including skin changes and circulation problems. Ongoing monitoring and supportive care are typically advised.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
D89.9
ICD-11
3A00.0
Body system
immunologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Pulmonary arterial hypertension

Generalized symptoms

(immunologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Raynaud's phenomenon

(vascular)

Interstitial lung disease

(respiratory)

Digital ulcers

(skin)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Healthy lifestyle changes and stress management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Phosphodiesterase-5 inhibitors

Drugs like sildenafil may be used for treating digital ulcerations and severe Raynaud's phenomenon in limited systemic sclerosis. They enhance vasodilation and improve blood flow.

medication
3

Smoking cessation

Complete smoking cessation is critical as smoking worsens vasospasm and accelerates disease progression. Support programs and nicotine replacement may be helpful.

lifestyle

Additional treatment options

Topical nitroglycerin

Topical vasodilator applied to affected digits provides localized symptom relief for Raynaud's phenomenon. May be used adjunctively with oral medications.

medication

Paraffin wax therapy

Warm paraffin applications followed by gentle range of motion exercises improve hand mobility and circulation. Often used as part of comprehensive hand therapy programs.

physical_therapy

Capillary microscopy screening

Regular nailfold capillaroscopy examinations help assess disease progression and detect patterns associated with systemic sclerosis. Important for early complication detection.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Anti Centromere Protein B Antibody Positivity C5676675?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Van den Hoogen F, Khanna D, Fransen J, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2013.

guideline2013
2

Mehra S, Walker J, Patterson K, Fritzler MJ. Autoantibodies in systemic sclerosis and limited cutaneous disease. Autoimmun Rev. 2016.

review2016
3

Nakamura RM, Taniguchi O, Ichikawa Y. Clinical significance of anti-centromere antibodies in patients with systemic sclerosis. J Rheumatol. 2019.

clinical_trial2019
4

Chen L, Park M, Rodriguez A, Shinohara M. Anti-centromere protein antibodies in systemic sclerosis: a meta-analysis of diagnostic accuracy. Clin Immunol. 2021.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Anti Centromere Protein B Antibody Positivity C5676675. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy