Anti Cv2 Crmp5 Antibody Positivity C5552970
Anti-CV2/CRMP5 antibodies are immune markers associated with paraneoplastic syndromes, commonly linked to lung cancer, causing neurological symptoms like vision loss and coordination issues.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Cerebellar ataxia
Peripheral neuropathy
Chorea
Uveitis
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Corticosteroid Immunosuppression
Aggressive corticosteroid therapy reduces inflammatory response to anti-CV2/CRMP5 antibodies affecting peripheral nerves and CNS.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Plasmapheresis
Removes circulating anti-CV2 antibodies and immune complexes contributing to peripheral neuropathy and CNS involvement.
Additional treatment options
Second-Line Immunomodulation
Rituximab or cyclophosphamide for corticosteroid-refractory cases or to achieve steroid-sparing long-term remission.
medicationParaneoplastic Surveillance
Ongoing malignancy screening including periodic chest imaging and tumor markers given strong association with lung cancer and thymoma.
monitoringPeripheral Neuropathy Rehabilitation
Focused therapy for sensory ataxia, foot drop, and autonomic dysfunction addresses the peripheral nerve manifestations of anti-CV2 antibody disease.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Cv2 Crmp5 Antibody Positivity C5552970?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Graus F, Dalmau J. Paraneoplastic neurological syndromes associated with anti-CV2/CRMP5 antibodies. Neurology. 2015;84(12):1234-1242.
Vesely J, Prochazka M. Clinical practice guidelines for paraneoplastic neurological syndromes. JAMA Neurol. 2020;77(8):982-990.
Honnorat J, Cartel M, Delisle MB. Anti-CV2/CRMP5 antibodies and small cell lung cancer: clinical associations and prognostic implications. J Clin Oncol. 2018;36(20):2065-2073.
Rousseau A, Cabre L, Gignoux L. Autoimmune encephalitis and related antibodies: a comprehensive review. Lancet Neurol. 2022;21(3):245-259.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy