Anti D Isoimmunization Affecting Pregnancy C3698348
Rh factor incompatibility during pregnancy when an Rh-negative mother develops antibodies against fetal red blood cells. Managed with careful monitoring.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Varies
Pallor
(hematologic)Jaundice
(hematologic)Shortness of breath
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Rh Immunoglobulin Prophylaxis
Administration of anti-D immunoglobulin to Rh-negative mothers to prevent sensitization. Given at 28 weeks gestation and within 72 hours after potentially sensitizing events such as delivery, abortion, or trauma.
Titers and Fetal Monitoring
Serial measurement of maternal anti-D antibody titers combined with Doppler ultrasound assessment of fetal middle cerebral artery peak systolic velocity to detect and monitor fetal anemia.
Additional treatment options
Intrauterine Transfusion
Direct transfusion of packed red blood cells to the fetus under ultrasound guidance when fetal anemia is confirmed. May require multiple procedures throughout pregnancy depending on severity.
procedurePlanned Delivery Management
Coordination of delivery timing and location based on fetal monitoring results. May include early delivery planning, availability of neonatal exchange transfusion, and delivery at a center with appropriate NICU resources.
surgicalNeonatal Phototherapy and Exchange Transfusion
Treatment of hyperbilirubinemia in affected newborns through intensive phototherapy and/or exchange transfusion to remove antibody-coated red cells and prevent kernicterus.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti D Isoimmunization Affecting Pregnancy C3698348?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
American College of Obstetricians and Gynecologists. Prevention of Rh D Alloimmunization. Practice Bulletin No. 181. Obstet Gynecol. 2017.
Urbaniak SJ, Greiss MA. RhD haemolytic disease of the newborn. Vox Sang. 2000;79(1):31-38.
Crowther CA, Middleton P, McBain RD. Anti-D administration in pregnancy for preventing Rhesus alloimmunisation. Cochrane Database Syst Rev. 2013;(2):CD000020.
Moise KJ Jr, Argoti PS. Management and prevention of red cell alloimmunization in pregnancy: a systematic review. Obstet Gynecol. 2012;119(6):1205-1216.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy