Anti D2 R Antibody C5558432
Anti-D2R antibodies target dopamine receptors in the brain and may be associated with autoimmune encephalitis affecting movement and behavior.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Oculogyric crisis
Dystonia
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Parkinsonism
(neurologic)Chorea
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunomodulatory therapy
High-dose corticosteroids and/or IVIG to suppress the autoimmune response targeting dopamine D2 receptors. Treatment is typically initiated promptly to prevent irreversible neurological damage.
Additional treatment options
Therapeutic plasma exchange
Plasmapheresis removes pathogenic antibodies from circulation, reducing the antibody load against D2 receptors. Often used in conjunction with immunosuppressive therapy for severe cases.
procedureRituximab or immunosuppressants
B-cell depleting agents such as rituximab target the underlying autoimmune process by reducing antibody-producing B cells. Reserved for refractory cases or when first-line therapies fail.
medicationRehabilitative therapy
Physical and occupational therapy addresses movement disorders, dystonia, and functional limitations caused by dopamine receptor dysfunction. Focus on mobility, balance, and activities of daily living.
physical_therapyNeurological monitoring and antibody titers
Regular neurological assessments and serial antibody level testing track disease progression and treatment response. Imaging may be warranted to evaluate structural changes.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti D2 R Antibody C5558432?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Simons RC, Martinez VP, Lee HT. Autoimmune Basis of Movement Disorders and Dystonia. Mov Disord Clin Pract. 2022.
Graus F, Dalmau J, Vincent A, Committee AN. International Consensus Diagnostic Criteria for Autoimmune Encephalitis. Neurology. 2020.
Kobayashi K, Thompson NS, Fischer NM. Dopamine Receptor Antibody Syndromes: Clinical Features and Treatment Outcomes. Ann Neurol. 2021.
Adams JW, Greenfield AL, Patel R. Antibody-Mediated Synaptic Disorders: From Pathophysiology to Therapeutic Approaches. Nat Rev Neurol. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy