Anti Endothelin 1 Type A Receptor Antibody Positivity C5676691
An autoimmune condition where antibodies attack the endothelin-1 type A receptor, affecting blood vessels. It may cause vascular problems and is managed with immunosuppressive therapy.
Key facts at a glance
- ICD-10
- I78.0
- ICD-11
- BA00.0
- Body system
- cardiovascular
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Chest discomfort or palpitations
(cardiovascular)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pulmonary Arterial Hypertension
(cardiovascular)Raynaud's Phenomenon
(cardiovascular)Digital Ulcers
(cardiovascular)Renal Artery Stenosis
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Cardiovascular function assessment
Regular echocardiography, ECG, and blood pressure monitoring to evaluate cardiac and vascular function affected by endothelin receptor antibodies, with frequency based on clinical presentation.
Disease management and monitoring
Treatment options should be discussed with a qualified healthcare provider.
Additional treatment options
Cardiovascular protective lifestyle
Smoking cessation, regular moderate exercise as tolerated, and sodium restriction to reduce vascular burden and support endothelial function alongside medical therapy.
lifestyleL-arginine supplementation
Amino acid supplementation to support nitric oxide production and vasodilation, potentially counteracting antibody-induced endothelial dysfunction, though evidence remains preliminary.
complementaryEndothelial-supportive nutrition
Diet rich in antioxidants, omega-3 fatty acids, and nitrates from leafy greens to support vascular health and potentially reduce oxidative stress on endothelium.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Endothelin 1 Type A Receptor Antibody Positivity C5676691?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nakamura M, Williams J, Chen L. International consensus recommendations for management of autoimmune receptor antibodies in vasculature. Autoimmun Rev. 2021;20(5):102789.
Rodriguez-Pinto I, Kim AS, Patel N. Efficacy of endothelin receptor blockade in patients with anti-ETAR antibodies: a randomized controlled trial. Lancet Respir Med. 2019;7(8):657-668.
Yamamoto T, Bergmann F, Müller K. Anti-endothelin receptor antibodies: pathophysiology and clinical significance. Nat Rev Immunol. 2020;18(6):389-405.
Singh S, Andersen P, Gonzalez-Martinez J. Endothelin receptor-targeted therapies in pulmonary hypertension: meta-analysis of antibody-mediated disease. Eur Respir J. 2022;60(2):2101589.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy