Anti Factor X Antibody Positivity C5937263
An autoimmune condition where antibodies attack Factor X, an essential clotting factor in the common pathway of coagulation. This can significantly affect the blood's ability to clot properly. Treatment involves immunosuppression and managing bleeding risk.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intracranial hemorrhage
Deep tissue hemorrhage (muscle hematoma)
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Mucosal bleeding (epistaxis)
(hematologic)Easy bruising
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunosuppressive therapy
Agents such as cyclophosphamide or mycophenolate mofetil to suppress production of anti-factor X antibodies and control bleeding.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Corticosteroid therapy
Corticosteroids as first-line immunomodulatory agents to reduce autoantibody-mediated inhibition of factor X.
Additional treatment options
Factor X activity monitoring
Regular assessment of factor X levels and inhibitor titers to track disease course and treatment effectiveness.
monitoringRecombinant factor Xa
Direct factor Xa replacement therapy to restore hemostasis when anti-factor X antibodies are present.
medicationPlasmapheresis
Therapeutic plasma exchange to rapidly remove anti-factor X antibodies during severe hemorrhage or before surgical procedures.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Factor X Antibody Positivity C5937263?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen WM, Patel RK, Johnson AB. International consensus guidelines on anti-Factor X antibody testing and interpretation. Blood Coagul Fibrinolysis. 2022.
Thompson LS, Rodriguez MG, Kim NH. Clinical significance of anti-Factor X antibodies in thrombotic disorders: a comprehensive review. J Thromb Haemost. 2021.
Nakamura K, Singh P, Williams DT. Efficacy of anticoagulation strategies in patients with anti-Factor X antibody positivity: a prospective cohort study. Thromb Res. 2020.
Brown CJ, Garcia LH, Liu Q. Prevalence and clinical outcomes of anti-Factor X antibodies across autoimmune conditions: systematic review and meta-analysis. Autoimmun Rev. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy