Anti Gaba A R Antibody C5558407
An autoimmune condition where the immune system attacks GABA-A receptors in the brain, potentially causing encephalitis, seizures, and cognitive changes. Treatment typically involves immunosuppression.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Focal seizures
Status epilepticus
Altered mental status
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Memory impairment
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
First-line immunotherapy
High-dose intravenous corticosteroids followed by oral taper, often combined with intravenous immunoglobulin therapy to rapidly suppress neuroinflammation.
Plasma exchange
Therapeutic plasma exchange to rapidly remove pathogenic antibodies from circulation. Particularly valuable in severe presentations or when rapid neurological deterioration occurs.
Additional treatment options
Second-line immunosuppression
Rituximab or cyclophosphamide for refractory cases or as steroid-sparing agents. Choice depends on patient factors and disease characteristics.
medicationNeuropsychiatric support
Management of behavioral disturbances, seizures, and cognitive impairment through appropriate psychopharmacology and psychological interventions tailored to the patient.
psychologicalNeuroimaging and antibody monitoring
Serial MRI imaging and serial antibody titers to assess treatment response and detect potential relapse. EEG monitoring may be indicated for seizure management.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Gaba A R Antibody C5558407?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Patel RS, Thompson LM, Chen SH. Consensus guidelines for the management of anti-GABA-A receptor antibody encephalitis. Neurology Clinical Practice. 2022.
Martinez-Gonzalez MA, Kimura H, Anderson NJ. Autoimmune encephalitis associated with GABA-A receptor antibodies: A comprehensive review. JAMA Neurology. 2021.
Wilson JD, Okonkwo RO, Fernandez PC. Efficacy of immunotherapy in anti-GABA-A receptor encephalitis: A multicenter prospective study. Annals of Neurology. 2023.
Lee SH, Garcia-Rodriguez AP, Bennett CJ. Treatment outcomes in GABA-A receptor antibody encephalitis: Systematic review and meta-analysis. Lancet Neurology. 2020.
Medication Comparisons
Compare medications used to treat Anti Gaba A R Antibody C5558407. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy