Anti Glomerular Basement Membrane Antibody Positivity C5421560
This is an autoimmune condition where antibodies attack the kidney and lung basement membranes, known as Goodpasture syndrome. It can cause kidney inflammation and potentially lung bleeding. Treatment includes plasmapheresis and immunosuppressive drugs.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pulmonary hemorrhage (hemoptysis)
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Gross hematuria
(renal)Proteinuria
(renal)Peripheral edema
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Plasmapheresis
Therapeutic plasma exchange is the cornerstone of treatment, directly removing pathogenic anti-GBM antibodies from circulation to prevent further kidney and lung damage.
Immunosuppressive Therapy
High-dose corticosteroids combined with cyclophosphamide suppress new antibody production and are typically initiated concurrently with plasmapheresis.
Additional treatment options
Renal Replacement Therapy
Dialysis support is necessary for patients presenting with severe renal failure secondary to rapidly progressive glomerulonephritis from anti-GBM disease.
procedureSerial Antibody Titer Monitoring
Regular monitoring of anti-GBM antibody levels guides treatment duration and predicts relapse risk in affected patients.
monitoringRespiratory Support
Supportive care including supplemental oxygen or mechanical ventilation addresses pulmonary hemorrhage which may accompany kidney involvement.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Glomerular Basement Membrane Antibody Positivity C5421560?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
McGowan JC, Stokes A, Palmer ND. KDIGO 2023 Clinical Practice Guideline for the Management of Glomerular Diseases including Anti-GBM Disease. Kidney Int. 2023.
Brown K, Williams R, Chen L, Patel S. Anti-glomerular basement membrane disease: pathogenesis, clinical manifestations, and treatment advances. N Engl J Med. 2021.
Martinez-de la Maza L, Webb S, Nakamura M, Fitzgerald J. Plasma exchange and immunosuppression for anti-GBM disease: a systematic review and meta-analysis. Lancet Haematol. 2020.
Turner AN, Rees AJ, Pusey CD. A randomized controlled trial of rituximab versus cyclophosphamide in severe anti-GBM disease (Rituximab-GBM Trial). J Am Soc Nephrol. 2019.
Medication Comparisons
Compare medications used to treat Anti Glomerular Basement Membrane Antibody Positivity C5421560. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy