Anti Glomerular Basement Membrane Disease C0403529
An autoimmune disorder where the body attacks the basement membrane in the kidneys and sometimes lungs. It can cause kidney damage and breathing difficulties, and treatment often involves medications to suppress the immune system.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Changes in urination or swelling
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Hemoptysis
Dyspnea
(renal)Peripheral edema
(renal)Oliguria
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Requires immediate emergency medical intervention. Do not delay treatment.
Therapeutic plasmapheresis
Plasmapheresis removes pathogenic anti-GBM antibodies from the bloodstream, reducing immune-mediated damage to kidney and lung tissues. This procedure is typically performed daily or every other day for 2-3 weeks depending on antibody levels.
Immunosuppressive therapy
High-dose corticosteroids combined with cyclophosphamide or rituximab suppress antibody production and reduce inflammation. This addresses the underlying autoimmune process driving the disease.
Additional treatment options
Dialysis support
When anti-GBM disease causes acute kidney injury with severe dysfunction, renal replacement therapy becomes necessary. This may be temporary or progress to end-stage kidney disease requiring long-term dialysis.
procedureRenal and pulmonary function monitoring
Regular assessment of serum creatinine, estimated glomerular filtration rate, and pulmonary function tests tracks disease progression and treatment response. Serial anti-GBM antibody titers guide therapy duration.
monitoringKidney transplantation
For patients who progress to end-stage renal disease despite treatment, kidney transplantation may be considered after disease remission is confirmed. Pre-transplant evaluation assesses overall fitness for surgery.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Anti Glomerular Basement Membrane Disease C0403529?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases. Kidney Int. 2021;100(4S):S1-S276.
McAdoo SP, Pusey CD. Anti-Glomerular Basement Membrane Disease. Clin J Am Soc Nephrol. 2017;12(7):1162-1172.
Wang J, Chen F, Liu Y, et al. Therapeutic Plasma Exchange in Anti-GBM Disease: A Systematic Review and Meta-Analysis. J Clin Apher. 2022;37(4):357-370.
Greenhall GH, Salama AD. Update on the Management of Anti-GBM Disease. Curr Opin Nephrol Hypertens. 2023;32(3):252-259.
Medication Comparisons
Compare medications used to treat Anti Glomerular Basement Membrane Disease C0403529. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy