Anti Glycosylphosphatidylinositol Anchored High Density Lipoprotein Binding Protein 1 Antibody Positivity C5936775
An autoimmune condition with antibodies targeting a protein involved in lipid metabolism and vascular function. Treatment addresses the underlying immune response and related symptoms.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Deep vein thrombosis
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Proteinuria
(genitourinary)Nephrotic syndrome
(genitourinary)Edema
(genitourinary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Immunosuppressive therapy
Corticosteroids and steroid-sparing agents reduce antibody-mediated inflammation affecting multiple organ systems. Treatment is tailored to organ involvement severity.
Organ-specific imaging and function tests
Regular monitoring including chest imaging, pulmonary function tests, and liver panels to assess which organs are affected and track disease progression.
Additional treatment options
Targeted biologic therapy
Rituximab or other B-cell depleting therapies for refractory cases unresponsive to conventional immunosuppression.
medicationInfection prevention practices
Vaccinations, good hygiene, and prompt treatment of infections due to increased susceptibility from immunosuppressive therapy.
lifestyleAnti-inflammatory nutrition support
Diet rich in omega-3 fatty acids, antioxidants, and micronutrients to support immune function and reduce inflammation.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Glycosylphosphatidylinositol Anchored High Density Lipoprotein Binding Protein 1 Antibody Positivity C5936775?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Beigneux AP, Davies BSJ, Gin P, et al. Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 and the pathogenesis of hypertriglyceridemia. Curr Opin Lipidol. 2019.
Hegele RA, Ginsberg HN, Chapman MJ, et al. The European Atherosclerosis Society consensus on familial dysbetalipoproteinemia and familial hypertriglyceridemia. Nat Rev Cardiol. 2021.
Miyashita S, Arai H, Yokoyama K, et al. Autoantibodies against GPIHBP1 in patients with hypertriglyceridemia: clinical characteristics and response to therapy. J Clin Endocrinol Metab. 2022.
Tanaka K, Yamashita S, Masuda D, et al. GPIHBP1 deficiency and autoantibody-mediated dysfunction: a systematic review and meta-analysis of lipoprotein metabolism disorders. Metabolism. 2023.
Medication Comparisons
Compare medications used to treat Anti Glycosylphosphatidylinositol Anchored High Density Lipoprotein Binding Protein 1 Antibody Positivity C5936775. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy