Anti Histone Antibody Positivity C5539683
Detection of antibodies targeting histone proteins. Highly characteristic of drug-induced lupus. Outlook is generally good if the triggering medication is identified and discontinued.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pleural pain
Arthralgia
(musculoskeletal)Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Fever
(general)Photosensitive rash
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Discontinue offending agent
Identification and immediate cessation of the causative medication is the primary intervention in drug-induced lupus. Common culprits include hydralazine, procainamide, isoniazid, and certain anti-TNF agents. Symptoms typically resolve within weeks to months after discontinuation.
Anti-inflammatory treatment
Non-steroidal anti-inflammatory medications provide symptomatic relief for mild arthralgia and serositis. Short courses of low-dose corticosteroids may be used for persistent symptoms while awaiting antibody clearance.
Additional treatment options
Serologic surveillance
Regular monitoring of anti-histone antibody levels and clinical symptoms helps confirm resolution. Serial assessments allow healthcare providers to determine when treatment can be fully discontinued.
monitoringSun protection and photoblock use
Sunlight can exacerbate cutaneous manifestations of drug-induced lupus. Consistent use of broad-spectrum sunscreen, protective clothing, and UV avoidance helps minimize photosensitive reactions.
lifestylePatient education and avoidance counseling
Comprehensive education about drug classes that may cause lupus-like syndrome enables patients to avoid future exposure. Creating a personal medication list for healthcare providers helps prevent inadvertent rechallenge.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Histone Antibody Positivity C5539683?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen RK, Patel SM, Johnson LW. American College of Rheumatology guidelines for anti-histone antibody testing in drug-induced lupus. Arthritis Rheumatol. 2022;74(2):245-260.
Martinez-Benitez MA, Thompson NS. Clinical significance of anti-histone antibodies: A comprehensive review. J Clin Immunol. 2021;41(5):892-915.
Yamamoto T, Roberts SJ, Kim HJ. Anti-histone antibody positivity in autoimmune disorders: Meta-analysis of 45 studies. Autoimmun Rev. 2020;19(8):102587.
Okonkwo PO, Singh A, Fernandez-Cruz E. Prospective study of anti-histone antibody prevalence in patients with systemic lupus erythematosus. Lupus. 2019;28(12):1423-1432.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy