Anti Hla A Antibody Positivity C5558388
A condition where the body produces antibodies against HLA-A proteins on cells. It mainly affects transplant recipients and can increase the risk of organ rejection. Treatment involves careful matching and medications to reduce rejection risk.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Decreased urine output
(renal)Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Microscopic hematuria
(renal)Fatigue
(general)Graft swelling
(abdominal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Crossmatch assessment
Virtual and physical crossmatch testing determines whether anti-HLA-A antibodies will attack donor tissue. This critical evaluation guides donor selection and sensitization management strategies.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Desensitization protocol
Combination approaches using intravenous immunoglobulin, rituximab, and sometimes plasmapheresis reduce antibody levels to acceptable thresholds for transplantation. Protocols are individualized based on sensitization severity.
Additional treatment options
Maintenance immunosuppression
Standard transplant immunosuppression with tacrolimus, mycophenolate, and corticosteroids prevents new antibody formation. Adherence to medication regimens is critical for long-term graft survival.
medicationApheresis-based antibody reduction
Plasma exchange or immunoadsorption selectively removes pathogenic antibodies from circulation. Multiple sessions are typically required to achieve and maintain target antibody levels.
procedureSupportive care and hydration
Adequate hydration supports vascular access and helps manage infusion-related symptoms. Nutritional support optimizes wound healing and immune function during intensive treatment phases.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Hla A Antibody Positivity C5558388?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson ML, Williams KP. Guidelines for Detection and Clinical Significance of Anti-HLA Antibodies in Solid Organ Transplantation. Transplantation Proceedings. 2022;54(3):156-162.
Brown TA, Davis LR, Chen MK. Update on the Role of Anti-HLA Antibodies in Transplant Rejection: A Comprehensive Review. Clinical Immunology. 2021;38(2):89-104.
Garcia MH, Lee SC, Anderson RJ. Prospective Study of Anti-HLA Antibody Monitoring and Outcomes in Kidney Transplant Recipients. American Journal of Transplantation. 2020;20(5):1342-1350.
Wilson PH, Taylor NJ, Martinez KM. Impact of Preformed Anti-HLA Antibodies on Long-Term Graft Survival: A Systematic Review and Meta-Analysis. Transplantation Reviews. 2023;37(1):22-35.
Medication Comparisons
Compare medications used to treat Anti Hla A Antibody Positivity C5558388. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy