Anti Hla A Igg1 Antibody Positivity C5558389
A specific subtype of antibody targeting HLA-A proteins, classified by its IgG1 structure. This antibody can contribute to transplant rejection by attacking donor cells. Monitoring and immunosuppressive therapy help manage this condition.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest discomfort
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Fever
(immunologic)Chills
(immunologic)Urticaria
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Therapeutic Plasma Exchange
Procedure that removes anti-HLA antibodies from circulation by separating plasma from blood cells and replacing with replacement fluids. Typically performed as a series of treatments until antibody levels are reduced.
Intravenous Immunoglobulin (IVIG)
High-dose IVIG modulates the immune system and can reduce antibody-mediated damage. Often used in combination with plasmapheresis for enhanced effect.
Additional treatment options
Rituximab Therapy
Monoclonal antibody targeting B-cells to reduce antibody production. Used in sensitized patients awaiting transplantation or with active antibody-mediated rejection.
medicationSerial Anti-HLA Antibody Monitoring
Regular measurement of antibody titers using solid-phase assays to track disease activity and treatment response. Essential for guiding therapy decisions.
monitoringDesensitization Protocol
Multimodal approach combining plasmapheresis, IVIG, and immunosuppression to lower alloantibody levels before solid organ transplantation.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Hla A Igg1 Antibody Positivity C5558389?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JF, Johnson RP, Williams KD. International consensus guidelines for the detection and monitoring of HLA antibodies in solid organ transplantation. Transplantation. 2021;105(8):1678-1690.
Brown LM, Davis PS. Clinical significance of pre-formed HLA antibodies in organ transplantation: a comprehensive review. Clin Immunol. 2019;203:45-58.
Garcia MA, Lee SH, Chen KH, Wilson AQ. Prospective multicenter evaluation of single-antigen bead assay for detection of HLA class I IgG antibodies. Am J Transplant. 2020;20(12):3456-3468.
Taylor NR, Anderson RC, Martinez JF, White HD. Impact of donor-specific HLA antibodies on allograft survival: systematic review and meta-analysis. J Heart Lung Transplant. 2022;41(6):742-755.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy