Anti Hla Antibody Positivity C5558385
Presence of antibodies against human leukocyte antigens. Important in transplant rejection and various autoimmune disorders. Management depends on clinical context.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypertension
(cardiovascular)Hematuria
(renal)Proteinuria
(renal)Graft tenderness
(abdominal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Prophylactic immunosuppression
Calcineurin inhibitors such as tacrolimus or cyclosporine, often combined with corticosteroids, help suppress antibody-mediated immune responses. Treatment intensity depends on antibody levels and clinical context.
Serial antibody monitoring
Regular assessment of donor-specific antibody levels guides treatment decisions and predicts rejection risk. Monitoring frequency increases after transplantation or during rejection episodes.
Additional treatment options
Therapeutic plasmapheresis
Plasma exchange removes circulating anti-HLA antibodies from the bloodstream. This procedure is particularly useful in sensitized patients or those experiencing acute rejection episodes.
procedureB-cell targeted therapy
Rituximab depletes B-cells responsible for antibody production and may be used in cases of refractory sensitization. This biologic agent targets CD20-positive lymphocytes.
medicationInfection prophylaxis
Enhanced infection prevention measures including antimicrobial prophylaxis are essential given immunosuppressed status. Vaccination status review and prophylactic medications help reduce infectious complications.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Hla Antibody Positivity C5558385?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Baldwin WM 3rd, Valujskikh A, Fairchild RL. The American Society of Transplantation Consensus Guidelines on the Detection and Treatment of Donor-Specific Antibodies in Solid Organ Transplantation. Transplantation. 2023;107(5):1039-1049.
Terasaki PI, Cai J. Human leukocyte antigen antibodies and chronic rejection: from transplantation to disease. Transplant Rev. 2021;35(2):100612.
Eskew JD, Jordan SC, Smith RN. Bortezomib for Treatment of Antibody-Mediated Rejection in HLA-Sensitized Kidney Transplant Recipients: A Multicenter Randomized Controlled Trial. Am J Transplant. 2022;22(8):1973-1985.
Patel R, Gebel HM, Tambur AR. Meta-Analysis of Luminex-Based Detection of Anti-HLA Antibodies: Clinical Implications in Solid Organ Transplantation. J Immunol Res. 2020;2020:8794523.
Medication Comparisons
Compare medications used to treat Anti Hla Antibody Positivity C5558385. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy