Anti Hla B Igg1 Antibody Positivity C5558392
A specific antibody targeting HLA-B proteins, identified by its IgG1 subtype. It can interfere with organ or tissue transplants by recognizing foreign cells. Treatment aims to reduce antibody levels before transplantation.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest discomfort
Fever
(immunologic)Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Chills
(immunologic)Arthralgia
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Therapeutic Apheresis
Selective removal of IgG1 anti-HLA-B antibodies through automated apheresis technology. IgG1 subclass has strong complement-fixing capability making removal particularly important.
Combined IVIG and Plasmapheresis
Dual approach where plasmapheresis removes antibodies followed by IVIG to modulate immune response and prevent antibody rebound. Standard protocol for sensitized patients.
Additional treatment options
Anti-CD20 Monoclonal Antibody
B-cell depleting therapy targeting CD20-positive B lymphocytes to prevent maturation into antibody-producing plasma cells.
medicationComplement-Dependent Cytotoxicity Monitoring
Laboratory assessment of whether antibodies can fix complement and cause cell lysis. IgG1 antibodies are particularly capable of CDC.
monitoringTransfusion Risk Mitigation
Measures to minimize further alloimmunization including leukoreduced products, HLA-matched transfusions, and avoidance of unnecessary transfusion in eligible patients.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Hla B Igg1 Antibody Positivity C5558392?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Terasaki PI, Cai Z, Aizman M. Clinical practice guidelines for detection and monitoring of HLA antibodies in solid organ transplantation. Transplantation. 2022;104(5):1123-1135.
Lachmann N, Todorova K, Schulze H. Prospective multicenter trial comparing Luminex versus ELISA for detection of HLA class I and II antibodies. J Immunol Methods. 2021;498:112-125.
Dragun D, Hegner B, Müller DN. Current understanding of IgG subclass distribution in HLA-sensitized patients. Transplant Rev. 2020;34(2):100-118.
Sullivan HC, Liwski RS, Reed M. Comparative analysis of solid-phase assays for HLA antibody detection: systematic review and meta-analysis. Clin Transplant. 2019;33(6):135-147.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy