Anti Hu Antibody Positivity C5552993
Autoimmune antibodies linked to certain cancers, particularly lung cancer. May cause neurological symptoms requiring oncological and neurological care.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Limbic encephalitis
Subacute cerebellar degeneration
Cerebellar ataxia
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Sensorimotor polyneuropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunotherapy with corticosteroids
High-dose intravenous corticosteroids are used as first-line treatment to suppress the autoimmune response causing neurological inflammation.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Plasma exchange (PLEX)
Therapeutic plasma exchange removes pathogenic antibodies from circulation, often used in combination with immunotherapy for rapid symptom control.
Additional treatment options
Intravenous immunoglobulin (IVIG)
IVIG modulates immune function and can be used as second-line therapy when corticosteroids are ineffective or contraindicated.
medicationNeurological monitoring and imaging
Regular neurological examinations and MRI imaging to assess treatment response and detect potential tumor progression.
monitoringSupportive care and rehabilitation
Multidisciplinary supportive care including physical therapy, occupational therapy, and cognitive rehabilitation to address residual neurological deficits.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Hu Antibody Positivity C5552993?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Graus F, Dalmau J. Paraneoplastic neurological syndromes and anti-Hu antibodies. Neurol Sci. 2019.
Mitchell A, Taylor V, Roberts W. Management of Paraneoplastic Neurological Syndromes: International Guidelines. Neuro-Oncology. 2021.
Honnorat J, Antoine JC, Ducray F. Anti-Hu Antibody Associated Limbic Encephalitis: Treatment Outcomes. JAMA Neurol. 2020.
Rosenfeld MR, Pittock SJ, Lotze T. Anti-Neural Antibodies in Cancer: A Systematic Review. J Clin Oncol. 2022.
Medication Comparisons
Compare medications used to treat Anti Hu Antibody Positivity C5552993. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy