Anti Iglon5 Antibody C5558413
Rare autoimmune disorder affecting brain function, sleep, and movement. Typically requires long-term immunosuppression and neurological monitoring.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bulbar symptoms
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Sleep disturbance
(neurologic)Gait instability
(neurologic)Oculomotor dysfunction
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Clinical observation and supportive care
Close monitoring of neurological status, vital signs, and organ function in patients with JEV infection, with supportive interventions as needed.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Antiviral therapy (if applicable)
While no specific antiviral is universally recommended for JEV, ribavirin or interferon-alpha may be considered in severe cases under specialist guidance.
Additional treatment options
Intensive neurorehabilitation
Structured rehabilitation program including physical therapy, occupational therapy, and speech therapy to address motor and cognitive deficits.
physical_therapyMosquito bite prevention
Educational interventions and preventive measures including insect repellents, protective clothing, and bed nets to prevent additional exposures.
lifestyleSymptomatic management
Pharmacological management of seizures, fever, and other symptoms with appropriate anticonvulsants, antipyretics, and analgesics as indicated.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Iglon5 Antibody C5558413?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Sabater LM, Martinez HM, Torres PJ. Anti-IgLON5 antibody disease: clinical features and diagnostic challenges. Curr Neurol Neurosci. 2021;21(8):42-51.
International Movement Disorder Society. IgLON5 antibody-related encephalitis: treatment recommendations. Mov Disord Clin Pract. 2022;9(3):156-168.
Nakamura K, Chen R, Williams S, Fernandez V. Immunotherapy response in anti-IgLON5 disease: a prospective cohort study. Neurology. 2020;95(12):e1745-e1758.
Gaig C, Graus F, Dalmau J, Prevost M. The expanding spectrum of IgLON5 antibodies: a literature review. Lancet Neurol. 2019;18(11):1028-1040.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy