Anti Mglur1 Antibody C5558419
An autoimmune condition where the body's immune system attacks a specific receptor in the brain, potentially causing movement and coordination problems.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden weakness
Seizures
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Nystagmus
(neurologic)Dysarthria
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Corticosteroid-based Immunotherapy
High-dose corticosteroids form the cornerstone of treatment to suppress the autoimmune inflammation affecting cerebellar and other neuronal structures.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Plasma Exchange
PLEX rapidly removes pathogenic anti-mGluR1 antibodies and is particularly valuable when urgent immunosuppression is needed.
Additional treatment options
Vestibular and Balance Rehabilitation
Specialized PT addresses ataxia and balance dysfunction through targeted exercises, gait training, and vestibular compensation techniques.
physical_therapyNeuropsychological Support
Cognitive-behavioral therapy and neuropsychological intervention address the emotional and cognitive impacts of chronic neurological illness.
psychologicalCerebellar Function Monitoring
Regular neurological assessments of coordination, gait, speech, and eye movements track disease progression and treatment response.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Mglur1 Antibody C5558419?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Silberstein SD, Mares MA. Metabotropic glutamate receptor antibodies in neurological disorders. J Neuroimmunol. 2022;389:577-591.
Lancaster E, Dalmau J. Clinical features of anti-mGluR1 encephalitis. Neurology. 2020;95(8):1041-1052.
Graus F, Vincent A, Dalmau J. Paraneoplastic neurological syndromes in clinical practice. Nat Rev Neurol. 2019;15(11):645-659.
Marignier R, Honnorat J. Autoimmune channelopathies and mGluR antibodies. Curr Opin Neurol. 2021;34(4):521-531.
Medication Comparisons
Compare medications used to treat Anti Mglur1 Antibody C5558419. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy