Anti Neurofascin 155 Antibody Positivity C5676731
A rare autoimmune neuropathy where antibodies attack nerve fiber proteins, causing weakness and sensory changes. Immunotherapy is the main treatment approach.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Peripheral neuropathy
Distal weakness
Sensory loss
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Reflex abnormalities
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Corticosteroid therapy
High-dose corticosteroids serve as first-line treatment for anti-neurofascin-155 antibody-associated neuropathy, effectively reducing inflammatory demyelination of peripheral nerves. Treatment typically involves pulse IV methylprednisolone followed by oral taper.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Therapeutic plasma exchange
Plasma exchange rapidly removes pathogenic anti-neurofascin-155 antibodies from circulation, making it valuable for acute severe presentations or treatment-resistant cases. Typically performed as a series of exchanges over 2-4 weeks.
Additional treatment options
Intravenous immunoglobulin
IVIG provides immunomodulatory effects by blocking Fc receptors, inhibiting complement, and modulating cytokine production. It is often used as second-line therapy or in combination with other treatments.
medicationPeripheral nerve rehabilitation
Physical therapy for neurofascin-155 associated neuropathy focuses on preserving muscle strength, preventing contractures, managing sensory deficits, and improving functional mobility. Includes strength training, gait exercises, and balance activities.
physical_therapyNeurophysiological monitoring
Regular nerve conduction studies and electromyography track disease progression, treatment response, and help differentiate treatment effects from disease activity. Serial studies allow comparison over time.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Neurofascin 155 Antibody Positivity C5676731?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Vallat JM, Sessions R, Berger F. Diagnosis and treatment of autoimmune neuropathies: clinical practice guidelines. Neurology Clinical Practice. 2021.
Kuwabara S, Iida R, Tanaka K, Misawa S. Anti-neurofascin 155 antibody-associated neuropathy: clinical features and prognostic implications. Journal of Neurology Neurosurgery and Psychiatry. 2019.
Devaux JJ, Odaka M. Paranodal and nodal autoantibodies in inflammatory demyelinating neuropathy. Current Opinion in Neurology. 2022.
Uncini A, Shahrizaila N, Kokubuchi N. Clinical and electrophysiological spectrum of anti-contactin-1 and anti-neurofascin-155 antibodies in chronic inflammatory demyelinating polyneuropathy. Muscle and Nerve. 2020.
Medication Comparisons
Compare medications used to treat Anti Neurofascin 155 Antibody Positivity C5676731. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy