Anti Neuronal Intermediate Filament Antibody Positivity C5970382
A rare neurological condition where antibodies target neuronal intermediate filaments, potentially affecting nerve cell function. Treatment involves immunotherapy.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sensory neuropathy
Autonomic dysfunction
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Ataxia
(neurologic)Cognitive impairment
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
First-line immunotherapy
High-dose corticosteroids as initial immunosuppressive treatment to reduce antibody-mediated neuronal damage and inflammation in paraneoplastic neurological syndromes.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Second-line immunosuppression
Additional immunomodulatory agents such as intravenous immunoglobulin, rituximab, or cyclophosphamide for refractory cases or steroid-sparing purposes.
Additional treatment options
Paraneoplastic antibody surveillance
Regular monitoring of antibody titers and comprehensive cancer screening to identify and treat any underlying malignancy driving the autoimmune response.
monitoringNeurorehabilitation
Specialized physical therapy focusing on balance, coordination, and functional mobility to address any persistent neurological deficits from neuronal injury.
physical_therapyNeuropsychological support
Cognitive and emotional support services including counseling and strategies to address memory difficulties, anxiety, or depression commonly associated with neurological autoimmunity.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Neuronal Intermediate Filament Antibody Positivity C5970382?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Graus F, Saiz A, Dalmau J. Autoimmune antibodies against neuronal intermediate filaments in neurological disorders. Neurology. 2019.
Vincent A, Irani SR, Lang B. International consensus guidelines on the diagnosis of autoimmune encephalitis. Autoimmun Rev. 2021.
Dalmau J, Graus F. Antibody-mediated neuronal damage in autoimmune encephalitis: clinical features and outcomes. Ann Neurol. 2018.
McKeon A, Lennon VA, Pittock SJ. Systematic review of neuronal antibody prevalence in autoimmune neurological disease. JAMA Neurol. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy