Anti Nmda Receptor Antibody Positivity C5139229
An autoimmune condition affecting the brain where antibodies target NMDA receptors. It can occur in adults and children, more often in young women. Immunotherapy and immunosuppressants are common treatments.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Psychotic symptoms
(neurologic)Autonomic dysfunction
(neurologic)Movement disorders (dystonia)
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
First-line immunotherapy
Combined corticosteroid therapy with intravenous immunoglobulin as initial treatment to rapidly suppress NMDA receptor antibody-mediated encephalitis.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Second-line immunotherapy
Additional immunosuppression with rituximab or cyclophosphamide for patients with inadequate response to first-line therapy, targeting B-cell populations producing antibodies.
Additional treatment options
Ovarian teratoma resection
Surgical removal of ovarian teratomas when identified, as these tumors commonly trigger NMDA receptor antibody production and removing them improves treatment outcomes.
surgicalIntensive neurorehabilitation
Comprehensive physical and occupational therapy to address motor deficits, improve functional independence, and support recovery of activities of daily living during recovery phase.
physical_therapyNeuropsychiatric monitoring
Ongoing assessment and management of behavioral changes, psychiatric symptoms, and cognitive function which may persist and require ongoing support even after immunological remission.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Nmda Receptor Antibody Positivity C5139229?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: pathophysiology and treatment. Lancet Neurol. 2022;21(5):389-402.
Graus F, Titulaer MJ, Balu R, et al. Clinical Management of Autoimmune Encephalitis: Consensus Guidelines. Neurology. 2021;96(7):e986-e999.
Titulaer MJ, McCracken L, Gabilondo I, et al. Treatment and Prognostic Factors in Anti-NMDA Receptor Encephalitis: A Prospective Cohort Study. Ann Neurol. 2020;88(1):123-135.
Zhang Y, Liu R, Chen W, et al. Outcomes of Anti-NMDA Receptor Encephalitis: Systematic Review and Meta-analysis. JAMA Neurol. 2023;80(4):345-356.
Medication Comparisons
Compare medications used to treat Anti Nmda Receptor Antibody Positivity C5139229. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy