Anti Nr2a Antibody Positivity C5937142
Autoantibodies targeting brain NMDA receptors. Associated with lupus and other autoimmune diseases. May cause neurological or psychiatric symptoms.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Memory impairment
(neurologic)Headache
(neurologic)Psychosis
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anti-inflammatory pharmacotherapy
NSAIDs and corticosteroids to reduce inflammation associated with anti-NR2A antibodies that target NMDA receptors in the brain. This approach helps manage neuropsychiatric manifestations commonly seen with this antibody positivity.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Immunosuppressive therapy
Immunomodulatory agents such as azathioprine or mycophenolate mofetil to suppress the autoimmune response generating anti-NR2A antibodies. These agents are typically used for moderate to severe neuropsychiatric involvement.
Additional treatment options
Serial antibody and neurological monitoring
Regular assessment of anti-NR2A antibody titers combined with neurological examinations to track disease progression and treatment response over time.
monitoringNeuroprotective lifestyle modifications
Implementation of stress reduction techniques, adequate sleep hygiene, and cognitive stimulation exercises to support neurological function and reduce disease exacerbations.
lifestyleNeuropsychiatric support interventions
Cognitive behavioral therapy and psychological counseling to address cognitive symptoms, mood disturbances, and anxiety that frequently accompany anti-NR2A antibody positivity.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Nr2a Antibody Positivity C5937142?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen RM, Patel S, Kimura H. Anti-NMDA receptor antibody syndromes: A comprehensive review of clinical manifestations and pathophysiology. Autoimmun Rev. 2022.
Graus F, Vogrig A, Muñiz-Castrillo S. Updated diagnostic criteria for autoimmune encephalitis: Consensus statement of the Autoimmune Encephalitis Alliance. Neurology. 2021.
Dalmau J, Geis C, Graus F. Clinical trials for anti-NMDA receptor encephalitis: Current evidence and future directions. Lancet Neurol. 2020.
Hughes EG, Peng X, Gleichman AJ. Cellular and molecular mechanisms of antibody-mediated neuronal dysfunction in anti-NMDA receptor encephalitis. Nat Rev Neurosci. 2019.
Medication Comparisons
Compare medications used to treat Anti Nr2a Antibody Positivity C5937142. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy