Anti Sox1 Antibody C5558427
Paraneoplastic antibody associated with small cell lung cancer and neurological syndromes. Warrants cancer screening and targeted care.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Cerebellar ataxia
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Nystagmus
(neurologic)Dysarthria
(neurologic)Peripheral neuropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Immunotherapy
Immune-modulating therapies such as corticosteroids, IVIG, or rituximab may be used to reduce antibody-mediated neurological damage. Treatment selection depends on neurological manifestations and severity.
Tumor resection
Identification and removal of underlying malignancy when paraneoplastic syndrome is suspected. Treating the root cause may lead to neurological improvement.
Additional treatment options
Plasmapheresis
Therapeutic plasma exchange to remove pathogenic antibodies from circulation. Often used in combination with immunotherapy for rapid antibody reduction.
procedureNeurorehabilitation
Targeted physical and occupational therapy to maintain function, improve strength, and enhance quality of life during and after treatment.
physical_therapyNeurological monitoring
Regular neurological assessments to track disease progression, treatment response, and detect new neurological deficits.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Anti Sox1 Antibody C5558427?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Graus F, Vogrig A, Muñiz-Castrillo S. Autoantibodies in paraneoplastic neurological syndromes: Focus on anti-SOX1 antibodies. Neurology. 2021.
Dyer MJ, Gatto-Ramos R, Titulaer MJ. Paraneoplastic neurological syndromes: Clinical practice guideline. Ann Neurol. 2020.
Pittock SJ, Lennon VA. Anti-SOX1 antibodies in LEMS and small cell lung cancer: A prospective cohort study. JAMA Neurol. 2019.
Zuliani L, Sabater L, Saiz A. Voltage-gated calcium channel antibodies in neurological disease: Meta-analysis. Brain. 2018.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy