Anti Thyroid Stimulating Hormone Receptor Antibody Positivity C5676780
Antibodies that overstimulate the thyroid, causing hyperthyroidism. Most common in adult women. Treated with medications, radioactive iodine, or surgery.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Weight loss
(endocrine)Heat intolerance
(endocrine)Tremor
(endocrine)Exophthalmos
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antithyroid medications
Thionamides such as methimazole or propylthiouracil to reduce thyroid hormone production by blocking hormone synthesis.
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Beta-blockers
Symptomatic relief of tachycardia, tremor, and anxiety using beta-adrenergic blocking agents while awaiting definitive treatment.
Additional treatment options
Radioactive iodine ablation
I-131 therapy to destroy overactive thyroid tissue. Definitive treatment option for patients who do not desire future pregnancy.
procedureThyroidectomy
Surgical removal of the thyroid gland for rapid control of hyperthyroidism or when other treatments are contraindicated.
surgicalLow-iodine diet
Dietary modification to reduce iodine intake, which may enhance effectiveness of radioactive iodine treatment.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Anti Thyroid Stimulating Hormone Receptor Antibody Positivity C5676780?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Ross DS, Burch HB, Cooper DS, et al. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid. 2016.
Barbaros B, Yilmaz SC, Korkmaz H. Clinical significance of TSH receptor antibodies in thyroid diseases. J Endocrinol Invest. 2021.
Chen XM, Wang LM, Liu JP, Sun H. Association between thyroid receptor antibodies and pregnancy outcomes in women with hyperthyroidism: a meta-analysis. Clin Endocrinol. 2022.
Nakamura S, Sato K, Ito T, Yamamoto M. Comparison of methimazole versus propylthiouracil in TRAb-positive Graves' disease patients: a randomized controlled trial. Eur J Endocrinol. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy