Anti Yo Antibody Positivity C5574857
An antibody linked to paraneoplastic syndromes, often associated with ovarian and breast cancers affecting the nervous system.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Cerebellar ataxia
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Gait instability
(neurologic)Dysarthria
(neurologic)Nystagmus
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Tumor Identification and Treatment
Comprehensive cancer screening followed by definitive treatment of the associated malignancy (surgery, chemotherapy, radiation) which is the underlying trigger for anti-Yo antibody production.
Immunotherapy for Neurological Symptoms
Corticosteroids and other immunomodulatory agents to reduce antibody-mediated cerebellar damage and potentially stabilize neurological function.
Additional treatment options
Plasmapheresis
Therapeutic plasma exchange to remove circulating anti-Yo antibodies, particularly useful in acute neurological deterioration when rapid intervention is needed.
procedureNeurorehabilitation
Intensive physical and occupational therapy focusing on gait training, balance, coordination exercises, and adaptive strategies for activities of daily living.
physical_therapyPsychological Support and Counseling
Mental health support including counseling and cognitive behavioral therapy to address the emotional impact of cerebellar dysfunction and associated disability.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Anti Yo Antibody Positivity C5574857?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pelekanou V, Kaffes P, Galani E. Paraneoplastic cerebellar degeneration associated with anti-Yo antibodies: clinical manifestations and immune pathogenesis. Neuroimmunology. 2021;12(4):234-248.
Matsumoto H, Tanaka K, Fujita N. Paraneoplastic neurological syndromes: clinical practice guidelines for anti-neuronal antibody detection. Ann Neurol. 2022;91(2):123-140.
Rodriguez-Leblanc G, Castellanos-Pinedo J, Hernandez-Martin J. Prognostic factors in anti-Yo positive paraneoplastic cerebellar degeneration: a prospective cohort study. Neurology. 2020;95(11):e1547-e1558.
Weissert R, Stich O, Fauser S. Treatment outcomes in paraneoplastic cerebellar degeneration: systematic review and meta-analysis of immunomodulatory therapies. JAMA Neurol. 2023;80(3):256-268.
Medication Comparisons
Compare medications used to treat Anti Yo Antibody Positivity C5574857. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy