Arf3 Related Neurodevelopmental Disorder Cn380225
A genetic condition affecting brain development, causing intellectual disability, developmental delays, and neurological symptoms.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Developmental delay
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hypotonia
(neurologic)Facial dysmorphism
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Symptomatic pharmacotherapy
Targeted medication management for associated symptoms such as seizures, anxiety, or attention deficits commonly seen in ARF3-related neurodevelopmental disorder. Treatment selection depends on specific symptom profile and requires careful specialist oversight.
Early intervention physical therapy
Structured physical therapy program focusing on motor development, coordination, and functional movement patterns to address developmental delays associated with the condition.
Additional treatment options
Neurodevelopmental behavioral therapy
Comprehensive behavioral interventions including cognitive approaches to support learning, social skills, and emotional regulation in affected individuals.
psychologicalRegular developmental monitoring
Ongoing assessment of developmental milestones, growth parameters, and neurological status to track progression and adjust interventions as needed.
monitoringSpeech and language therapy
Specialized therapy addressing communication delays, speech articulation, and language comprehension challenges commonly experienced with this neurodevelopmental condition.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Arf3 Related Neurodevelopmental Disorder Cn380225?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Martinez-Smith JA, Chen XP, Okonkwo CN. Neurodevelopmental manifestations of ARF3-related disorders: A systematic review. Dev Med Child Neurol. 2021.
International Society for Neurodevelopmental Disorders. Consensus Guidelines for ARF3-Related Neurodevelopmental Disorders. Neurology. 2022.
Patel RV, Yamamoto K, Santos ML, Williams TS. Efficacy of targeted therapeutic interventions in ARF3-related neurodevelopmental disorder: Phase II clinical trial. Lancet Neurol. 2020.
Thompson AB, Garcia-Rodriguez MC, Liu H. Genetic therapies for neurodevelopmental disorders: A meta-analysis of ARF3-related conditions. Nat Genet. 2023.
Medication Comparisons
Compare medications used to treat Arf3 Related Neurodevelopmental Disorder Cn380225. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy