Arhgap29 Related Non Syndromic Orofacial Cleft Cn379772
A genetic condition causing cleft lip and/or palate without associated developmental features. Treatment typically involves surgical repair and multidisciplinary support including speech and dental care.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Cleft lip
(congenital)Generalized symptoms
(congenital)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Cleft palate
(congenital)Dental malocclusion
(congenital)Speech difficulties
(congenital)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Cleft lip and palate surgical repair
Multi-stage surgical reconstruction of the lip and palate performed by a craniofacial surgical team. Timing typically involves lip repair around 3-6 months and palate repair around 9-18 months of age.
Feeding support and management
Specialized feeding techniques and equipment including specialized nipples, positioning strategies, and collaboration with feeding therapists to ensure adequate nutrition intake during infancy.
Additional treatment options
Speech and language therapy
Early intervention speech-language pathology services to address velopharyngeal dysfunction, articulation difficulties, and language development delays associated with cleft palate.
physical_therapyPsychosocial support and counseling
Comprehensive psychological support for patients and families addressing body image concerns, social adjustment, and coping strategies throughout developmental stages.
psychologicalOrthodontic and dental interventions
Multi-phase orthodontic treatment including infant orthopedics, mixed dentition expansion, and comprehensive orthodontics. Dental care coordination with cleft team for optimal outcomes.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Arhgap29 Related Non Syndromic Orofacial Cleft Cn379772?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Leslie EJ, Marazita ML. Genetics of cleft lip and cleft palate. Am J Med Genet C Semin Med Genet. 2013;163(4):246-258.
American Cleft Palate-Craniofacial Association. Parameters for Evaluation and Treatment of Patients with Cleft Lip/Palate or Other Craniofacial Anomalies. Cleft Palate Craniofac J. 2020;57(5):597-612.
Jiang R, Liu M, Li C, et al. ARHGAP29 gene variants contribute to non-syndromic cleft lip with or without cleft palate in Chinese populations. J Hum Genet. 2019;64(10):1029-1036.
Wang M, Zhang SX, Chen Y, Liu H. Association between ARHGAP29 polymorphisms and non-syndromic orofacial clefts: A systematic review and meta-analysis. Int J Mol Sci. 2022;23(18):10489.
Medication Comparisons
Compare medications used to treat Arhgap29 Related Non Syndromic Orofacial Cleft Cn379772. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy