Arterial Calcification Generalized Of Infancy 2 C3276161
A rare condition where calcium builds up in arteries and tissues in babies. It is typically fatal in early childhood, with treatment focused on symptoms.
Key facts at a glance
- ICD-10
- I78.0
- ICD-11
- BA00.0
- Body system
- cardiovascular
- Severity
- fatal
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Chest discomfort or palpitations
Progressive symptoms that can become life-threatening without treatment.
Seek immediate medical attention if symptoms worsen.
Respiratory distress
Failure to thrive
(cardiovascular)Pulmonary hypertension
(cardiovascular)Renal artery stenosis
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Bisphosphonate therapy
Agents such as pamidronate may be considered to inhibit vascular calcification progression, though efficacy varies and treatment is largely experimental in this condition.
Disease management and monitoring
Treatment may require specialized care, hospitalization, or long-term management under medical supervision.
Cardiac and vascular surveillance
Regular echocardiography and vascular imaging to monitor calcification progression, cardiac function, and guide treatment decisions. Frequency determined by clinical severity.
Additional treatment options
Low-phosphate dietary management
Dietary phosphate restriction may help slow vascular calcification. Requires consultation with a pediatric dietitian to ensure adequate nutrition for growth.
dietaryMagnesium supplementation
Magnesium may act as a natural antagonist to calcium deposition in tissues. Theoretical benefit exists though clinical evidence is limited.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Arterial Calcification Generalized Of Infancy 2 C3276161?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Rutsch F, Nitschke Y, Moreno C. Arterial calcification syndromes in infancy and childhood. Nat Rev Cardiol. 2021.
Orphanet Working Group, Aegerter C, Bouvagnet P. Clinical practice guidelines for generalized arterial calcification of infancy. Orphanet J Rare Dis. 2020.
Li Q, Uygur B, Hsuen K. Novel ENPP1 mutations and clinical outcomes in generalized arterial calcification of infancy. J Clin Invest. 2022.
Ferreira CR, Hackbarth ME, Ziegler SG. Molecular diagnosis of generalized arterial calcification of infancy using whole-exome sequencing. Mol Genet Genomic Med. 2019.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy