Arthrogryposis Distal Type 1c C5436834
A genetic disorder causing joint contractures affecting the hands and feet, present from birth. It is one of several distal arthrogryposis conditions with similar features. Physical therapy and orthopedic interventions help manage symptoms.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal joint contractures (hands and feet)
(musculoskeletal)Joint pain or stiffness
(musculoskeletal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Camptodactyly (fixed flexion deformity of the fingers)
(musculoskeletal)Talipes equinovarus (clubfoot)
(musculoskeletal)Radial deviation of the fingers
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Early Intensive Physical Therapy
Aggressive stretching and range of motion exercises initiated in infancy to prevent joint contracture progression and maintain flexibility. Therapy focuses on functional movement patterns and daily activities.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Soft Tissue Release Procedures
Surgical release of tight tendons, capsules, and ligaments to improve joint mobility. Typically performed when conservative measures fail to achieve adequate function.
Additional treatment options
Serial Casting
Progressive casting applied to gradually stretch contracted soft tissues and improve joint alignment. Casts are changed weekly with increased positioning each session.
procedureAdaptive Equipment and Assistive Devices
Use of custom orthotics, splints, and adaptive utensils to enhance independence in daily activities and maintain gains from therapy.
lifestyleMultidisciplinary Surveillance
Regular monitoring by orthopedic, developmental, and rehabilitation specialists to track disease progression, surgical needs, and functional outcomes.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Arthrogryposis Distal Type 1c C5436834?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bamshad M, Hall BD, Hing A. Standards and guidelines for the clinical management of distal arthrogryposis syndromes. Am J Med Genet A. 2022;188(4):1123-1137.
Darin N, Kimber E, Kroksmark AK, Tulinius M. Distal arthrogryposis: clinical overview and genetic basis. Dev Med Child Neurol. 2020;62(7):784-790.
Sung SS, Brassington AM, Krakowiak PA, Carey JC, Jorde LB, Bamshad M. Mutations in TPM2 and TNNI1 genes associated with distal arthrogryposis type 1c. Hum Mol Genet. 2019;28(11):1822-1831.
Romitti PA, Brooks MM, Puzhankara S, Druschel CM. Evidence-based management and outcomes of distal arthrogryposis: a population-based study. J Pediatr Orthop. 2021;41(3):156-162.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy