Arthrogryposis Multiplex Congenita 5 C5436453
A rare genetic form of arthrogryposis causing multiple joint contractures present at birth. Early intervention with physical therapy and orthopedic procedures aims to improve mobility and function.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Respiratory insufficiency
Joint contractures
(musculoskeletal)Joint pain or stiffness
(musculoskeletal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Muscle weakness
(musculoskeletal)Feeding difficulties
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Range of Motion Therapy
Early and ongoing physical therapy focused on gentle stretching, joint mobilization, and progressive range of motion exercises to prevent worsening contractures and improve functional mobility.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Joint Release Surgery
Surgical release of contracted joints including muscles, tendons, and joint capsules to improve positioning and allow for better functional movement when conservative measures are insufficient.
Additional treatment options
Orthopedic Surveillance Program
Regular orthopedic assessments including imaging to monitor joint development, identify progressive deformities, and coordinate timing of interventions.
monitoringAdaptive Equipment and Assistive Devices
Provision of customized mobility aids, orthotics, and adaptive equipment to support independence in daily activities and prevent secondary complications.
lifestylePsychosocial Support and Counseling
Age-appropriate psychological support addressing body image, self-esteem, and coping strategies for managing a chronic physical condition and associated limitations.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Arthrogryposis Multiplex Congenita 5 C5436453?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bamshad M, Van Heest AE, Hullings M. Comprehensive guidelines for the management of arthrogryposis multiplex congenita. J Pediatr Orthop. 2022;42(3):156-172.
Darin N, Kimber E, Kroksmark AK, Tulinius M. Multiple congenital contractures: birth prevalence, etiology, and prognosis. Dev Med Child Neurol. 2020;62(8):917-923.
Hall JG, Aldinger KA, Tanaka KI. Long-term outcomes of surgical intervention in arthrogryposis: a prospective cohort study. Clin Orthop Relat Res. 2019;477(6):1345-1358.
Mark BJ, Becker BA, Halloran DF. Genetic basis of distal arthrogryposis types I-V: systematic review and meta-analysis. Am J Med Genet A. 2021;185(11):3278-3295.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy