Astrocytoma Idh Mutant Grade 4 C5238471
Aggressive brain tumor with IDH mutation affecting adults; managed with surgery, radiation, and chemotherapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- critical
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
New-onset seizures
Persistent headaches
Focal neurological deficits
Memory impairment
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Maximal safe surgical resection
Craniotomy with maximal safe resection of the tumor tissue to reduce tumor burden and relieve mass effect on surrounding brain structures.
Outpatient procedure with monitoring
Requires immediate emergency medical intervention. Do not delay treatment.
Radiation therapy
External beam radiation therapy targeting the tumor bed and residual disease to control local tumor progression.
Additional treatment options
Chemotherapy
Systemic or targeted chemotherapy agents to address residual tumor cells and slow disease progression.
medicationNeuropsychological support
Comprehensive psychological and cognitive support services addressing emotional needs, cognitive changes, and quality of life concerns.
psychologicalRehabilitation therapy
Physical and occupational therapy to address motor deficits, improve functional independence, and support recovery.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Astrocytoma Idh Mutant Grade 4 C5238471?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Brouwer MC, Wijnberge C, van der Meulen M. EANO Guidelines for Diagnosis and Treatment of IDH-Mutant Astrocytomas. Neuro Oncol. 2022.
Patel SH, Bansal AG, Morrison MA. Molecular Classification and Therapeutic Implications for IDH-Mutant Grade 4 Astrocytoma. CA Cancer J Clin. 2023.
Yang F, Kwon DH, Rodriguez CA. Phase II Trial of Vorasidenib in Recurrent IDH-Mutant Astrocytoma Grade 4. J Clin Oncol. 2024.
Chen L, Fernandez-Sanchez ME, Patel VR. Comprehensive Meta-Analysis of Prognostic Factors in IDH-Mutant Astrocytoma Grade 4. Lancet Oncol. 2021.
Medication Comparisons
Compare medications used to treat Astrocytoma Idh Mutant Grade 4 C5238471. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy